منابع مشابه
COVID-19: combining antiviral and anti-inflammatory treatments
The high affinity of baricitinib for the numb-associated kinase (NAK) family, its anti-inflammatory properties, with its advantageous pharmacokinetic properties, appear to make it a special case among the approved drugs. In addition, the potential for combination therapy with baracitinib is high, because of its low plasma protein binding and minimal interaction with CYP enzymes and drug transp...
متن کاملThe cost-effectiveness, health benefits, and financial costs of new antiviral treatments for hepatitis C virus.
BACKGROUND New hepatitis C virus (HCV) treatments deliver higher cure rates with fewer contraindications, increasing demand for treatment and healthcare costs. The cost-effectiveness of new treatments is unknown. METHODS We conducted a microsimulation of guideline testing followed by alternative treatment regimens for HCV among the US population aged 20 and older to estimate cases identified,...
متن کاملApplication of Bayesian Approach to Cost-Effectiveness Analysis of Antiviral Treatments in Chronic Hepatitis B
BACKGROUND Hepatitis B virus (HBV) infection is a major problem for public health; timely antiviral treatment can significantly prevent the progression of liver damage from HBV by slowing down or stopping the virus from reproducing. In the study we applied Bayesian approach to cost-effectiveness analysis, using Markov Chain Monte Carlo (MCMC) simulation methods for the relevant evidence input i...
متن کاملHepatocellular carcinoma and direct acting antiviral treatments: Controversy after the revolution.
Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris–Seine Saint-Denis, Site Jean Verdier, Pôle d’Activité Cancérologique Spécialisée, Service d’Hépatologie, Bondy, France; INSERM, Unité Mixte de Recherche (UMR) 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue contre le Cancer, Paris, France; Université Paris Descartes, Labex Immuno-Oncology, So...
متن کاملCost-effectiveness analysis of antiviral treatments for HBeAg-positive chronic hepatitis B in Canada.
OBJECTIVE To conduct a cost-effectiveness analysis of currently available nucleos(t)ide antiviral treatments (lamivudine, telbivudine, entecavir, and tenofovir) for chronic hepatitis B in Canada. METHODS Markov modeling was used to project the lifetime health benefits and costs associated with the antiviral treatments. The hypothetical patient population was hepatitis B e antigen-positive chr...
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ژورنال
عنوان ژورنال: Clinics in Chest Medicine
سال: 2017
ISSN: 0272-5231
DOI: 10.1016/j.ccm.2016.11.008